Overview
The Center for Modeling Pediatric Diseases (CMPD) plays a key role in providing that support. As a new initiative at St Jude Children’s Research Hospital (SJCRH), its mission is to serve the research community by delivering high-quality, fully-characterized, patient-derived, pluripotent cells.
Our aim is to generate these cells on our fully-automated, state of the art, robotic system. Our methodologies are based on the Nobel Prize winning work of Shinya Yamanaka, which culminated in the ability to create induced pluripotent stem cells (iPSCs) from terminally-differentiated human somatic cells such as skin cells, blood cells and urine cells. These iPSCs permit the derivation of both normal and disease phenotype, patient-matched cell lines, and are therefore key to developing personalized medicine approaches: iPSCs provide a vital tool to study the cellular and molecular mechanisms involved in patient-specific responses to treatments, and in the future will form the basis of creating patient-derived, patient-matched cellular therapeutics. There are opportunities to develop bioinformatics and data analysis skills, including running machine learning pipelines to evaluate microscope images of developing iPSC colonies. Our automation system includes the latest model instruments: Hamilton Vantage; Hamilton LabElite Decapper; Bionex Centrifuge; Cytation 5; Cytomat (500 capacity); KingFisher Flex; F7 robotic arm and a BioStore III Liquid Nitrogen Freezer.
As CMPD establishes our methodologies and implements our automation we seek an exceptional, self-motivated individual with experience in either cell biology with preferred expertise in robotics and automation or someone with a Biomedical or electrical engineering background that enjoys the thrill of working with a multidisciplinary team to create solutions that automates a series of manual cell culture workflows to aid in increasing stem cell reprogramming throughout. The transition from manual to automated workflows requires a highly-organized, methodical, and algorithmic mindset. This role provides an exceptional opportunity to acquire expertise in developing and implementing automation programming routines. Ability to demonstrate attention to detail is key, as is a desire to work in a highly reproducible manner, by close adherence to optimized SOPs. However, an ability to innovate, and determine where evolutions can be made to improve time and cost efficiencies, in coordination with the team, is also highly desirable.
If you are excited by using state-of-the-art instrumentation, if you are able to take a one-off research experiment and optimize it to make it unbreakably reproducible, and would like to do for biology what Henry T Ford did for car manufacturing, then we would like to hear from you!. A very strong desire to learn automation and process development skills are mandatory.
Responsibilities
- Operating and performing troubleshooting on robotic instrumentation
- Managing the use of all equipment by writing and implementing Standard Operating Procedures and coordination of all issue reporting and repairs
- Validation and Optimization of automated protocols
- Improving efficiency by standardizing of methods and protocols
- Keeping up to date with software on various automation instrumentation
- Assists with automated stem cell training
Minimum Education
- Bachelor’s degree in relevant scientific area is required.
Minimum Experience
Scientist
- Seven (7) years of relevant post-degree work experience is required.
- Five (5) years of relevant post-degree work experience is required with a Master’s degree.
- Three (3) years of relevant post-degree work experience is required with a PhD.
Lead Researcher
- Five (5) years of relevant, post-degree work experience is required with a Bachelor’s degree.
- Two (2) years of relevant post-degree work experience is required with a Master’s degree.
- No experience is required with a PhD degree.
Other Information
COVID-19 vaccine:
As of September 10, 2021, St. Jude Children’s Research Hospital has mandated the COVID-19 vaccine for all employees, excluding those with an approved medical or religious accommodation, as a condition of employment.
EEO Statement: St. Jude is an Equal Opportunity Employer
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