Summary
A postdoctoral position is open at The Center for Cell and Gene Therapy to conduct correlative/mechanistic studies in first-in-man Phase I clinical trials to understand mechanisms regulating leukemia and lymphoma resistance to CAR T-cell therapy and factors regulating the activity of engineered CAR T-cells in patients. Applicants are sought to design and perform correlative CAR T-cell studies on samples obtained in ongoing Phase I clinical trials of CAR T-cells as well as the GMP-manufactured CAR T-cell products. Clinical activity of CAR T-cells will be replicated in relevant PDX models.
Job Purpose
Postdoctoral Associates are trainees working in an apprenticeship mode in preparation for a career as a scientific professional.
Job Duties
- Designs and performs cell-based assays for high-throughput analyses of CAR T-cells (e.g., multimodal flow cytometry, RNA-seq).
- Analyzes multi-dimensional data in collaboration with the bioinformatics group.
- Establishes patient-derived xenograft models of leukemia and lymphoma for preclinical testing of next-generation products.
- Performs pilot experiments to test specific hypotheses in preclinical CAR-T cell development to inform the next generation of CAR T-cell therapies.
- Assists with writing reports and manuscripts and present at scientific meetings.
- Maintains a timely log of experimental notes.
Minimum Qualifications
- MD or Ph.D. in Basic Science, Health Science, or a related field.
- No experience.
Preferred Qualifications
- Ph.D in Immunology or Cell Biology strongly desired.
- Experience with immunology, mouse models, and high-throughput single-cell assays is a plus.
- Experience in cell biology and flow cytometry is strongly preferred.
- Experience with transcriptomics / high-throughout assays is a bonus.
Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.
Apply via Recruiter
To help us track our recruitment effort, please indicate in your email/cover letter where (ngotenders.net) you saw this job posting.